Successful vaccination of BALB/c mice against human hookworm (Necator americanus): the immunological phenotype of the protective response
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چکیده
منابع مشابه
Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus.
Blood-feeding parasites use mechanistically distinct proteases to digest hemoglobin (Hb), often as multienzyme cooperative cascades. We investigated the roles played by 3 distinct proteases from adults of the human hookworm Necator americanus. The aspartic protease Na-APR-1 and the cysteine protease Na-CP-3 were expressed in catalytically active form in yeast, and the metalloprotease Na-MEP-1 w...
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Experimental trials are underway exploring the use of parasitic helminthes to treat autoimmune diseases. As with any experimental therapy, such trials must adequately address safety concerns associated with the treatment protocol. In the treatment protocol employed by Autoimmune Therapies, patients are inoculated intradermally with the common nematode hookworm Necator Americanus. Beyond the pot...
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Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration.
The infective larvae of Necator americanus were shown to secrete all mechanistic classes of proteolytic enzymes with two overall pH optima of 6.5 and 8.5 using fluorescein isothiocyanate-labeled casein as the substrate. Since infective larvae are obligate skin penetrators, the effect of each of these enzyme classes against macromolecules derived from human skin was examined. Larval secretions w...
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ژورنال
عنوان ژورنال: International Journal for Parasitology
سال: 2003
ISSN: 0020-7519
DOI: 10.1016/s0020-7519(02)00248-5